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The World Bank is searching for meaning

By Noah Smith

PAUL ROMER’S departure last week as chief economist of the World Bank isn’t an event about just one man and his former job. His exit was undoubtedly influenced by individual factors, but it also illustrates broad challenges for the Bank as an institution.

Romer is, to put it bluntly, a contentious man. A celebrated researcher of economic growth, he has spent years vigorously attacking the ideas of his doctoral adviser, macroeconomist Robert Lucas, and the very field of macroeconomics itself. At the World Bank, his tenure has been marked by heated disputes, including one over how many times the word “and” should be used in official communications.

That sort of approach can be very useful in an academic setting. Indeed, many of Romer’s criticisms of macroeconomics were truths that others in the field had been afraid to speak (though I’m not so sure about his grammatical advice).

But when it comes to navigating the complex bureaucracy of an institution like the World Bank, perfectionism, bluntness, and prickly precision are not necessarily the most endearing traits.

But the bigger question concerns the Bank itself.

The immediate cause of Romer’s departure probably had to do with a public clash over the widely cited Ease of Doing Business rankings. This index, which the World Bank updates frequently, is intended to measure how easy it is to start a business in a particular country.

An accommodating business environment is assumed — both by the Bank and by many economists — to be a good thing. It’s believed to result in more creative destruction — the constant churning of industries and businesses that improves the economy through competition that eliminates inefficient producers. It also reduces monopoly power, by making it easier for new companies to enter a market and compete.

That’s the abstract theory, anyway. In reality, the ease of doing business is hard to measure — the Bank’s criteria might not capture the factors that are most important in encouraging business dynamism, or the rankings might weight the factors incorrectly. Rich countries tend to be ranked higher, but this might just be because countries make it easier to do business once they get rich.

Romer made headlines earlier this month when, speaking to reporters from the Wall Street Journal, he accused the Bank of changing its rankings unfairly. Romer noticed that changes in the factors used to construct the index had the effect of raising Chile’s ranking under conservative governments and lowering it under socialist ones. Romer later clarified that he didn’t mean to assert that politics was a factor in the Bank’s decisions, but nevertheless the damage to the reputation of the rankings, and of the Bank itself, could be long-lasting. Though Romer’s tenure as chief economist had been marked by many clashes, this battle was probably the last straw.

Political motivations or no, however, the overall usefulness of the Ease of Doing Business rankings is highly questionable. Many free-market enthusiasts, such as John Cochrane of the Hoover Institution, believe that if countries up their position in the World Bank’s rankings, growth will follow as a matter of course. But the evidence says otherwise.

In 2016, economics student and blogger Evan Soltas measured whether large increases in a country’s position in the rankings were followed by growth. He found no measurable effect, even in the long term, and that taking the World Bank’s advice on structural issues seems to do very little if anything for economic growth.

If Soltas’s result holds — and given the poor performance of other rankings of business conditions, it seems likely it will — it means that the World Bank has been recommending policies based more on faith and assumptions than on real hard evidence.

Since countries often work hard to improve their position in the rankings, this means that the Bank has probably been squandering its policy clout. And if reforms intended to climb up the rankings end up making societies less equal, the Bank could even have been having a negative impact on the world’s poor. That would be a mistake along the same lines as the one made by the Bank’s sister organization, the International Monetary Fund, which recommended fiscal austerity policies that it later admitted had hurt the countries they were designed to help.

If true, this would be bad for the World Bank, which has been suffering an identity crisis in recent years. Global growth means that few countries need or want the Bank’s development loans, leaving it searching for a reason to continue existing. Many had envisioned the Bank, which employs a large number of academically trained economists, functioning as a think tank to advise countries on how to boost growth. No one needs or wants a think tank that is known for giving bad advice.

So although Romer’s exit will take the World Bank out of the headlines for a while, the deeper questions about its future remain. Its problems are much bigger than one contentious chief economist.

BLOOMBERG

Recycling firm offers help in waste management

A RECYCLING company has urged the Davao City government to impose a stricter implementation of the segregation policy as it offered to take in plastic waste for the production of school chairs. Winchester O. Lemen, managing partner of Winder Recycling Company, said they have already talked with the City Environment and Natural Resources Office (CENRO) and are now awaiting action from the local government. “Right now the landfill is already filled and it is the objective of the plant to help reduce the plastic wastes of the city,” he said in an interview. Winder Recycling, based in Davao City, currently sources its plastic wastes — including candy wrappers and other food packaging materials — from the cities of Panabo and Tagum as well as the town of Polomolok. The company’s plant can process up to 90 tons of plastic waste and produce 2,000 school chairs per month. Mr. Lemen said their market for the chairs is currently just private schools, but they have already initiated talks with the Department of Education (DepEd) for procurement in public schools. — Maya M. Padillo

Pistons get Griffin

In assessing the value of National Basketball Association trades and determining which of those involved won, it’s fair to begin by addressing the query: Which team got the best player? In the case of the deal that went down yesterday, the Pistons did; they gave away two starters, an occasional substitute, and two draft picks for five-time All-Star Blake Griffin. And so the swap figures to weigh in their favor from the outset, especially since he possesses the star power that transcends his contributions on the court.

True, Griffin won’t come cheap. He just a signed a humongous contract that will net him a whopping $35 million in the first season and $171 million all told through 2022. Moreover, the Pistons seem to be have gutted its roster in doing so; Tobias Harris and Avery Bradley are solid players, and they can’t be easy to replace (not to mention aren’t — and won’t be — commanding eye-popping price tags). And with the injury to point guard Reggie Jackson, the immediate future looks to be a whole lot of their new acquisition and resident front court anchor Andre Drummond.

On the other hand, the Pistons had little to no choice but to do something — anything, really — to salvage their campaign. Prior to unrolling the welcome mat for Griffin, they were in the midst of a debilitating swoon that threatened to further erode their already-suspect fan base. Now, they have a proven marquee name that will put backsides in seats and sell the future with no small measure of truth attached to the promises. And because they’re in the diluted East, playoff stints, however short, should be part and parcel of their concrete plans.

To be sure, Griffin is a risky proposition. He’s supposed to be in his prime years, but his brittle body has killed the momentum his talent built in his nine years with the Clippers. Needless to say, the Pistons hope he gets to suit up more often that he did in La-La Land; else, he’ll be an albatross, paid premium wages for part-time work. In any case, he’s a much-needed shot in the arm for a franchise flailing in mediocrity. Now, they’ll be good, maybe even better than good, grinding in the present even as they have hope for the future.

 

Anthony L. Cuaycong has been writing Courtside since BusinessWorld introduced a Sports section in 1994. He is the Senior Vice-President and General Manager of Basic Energy Corp.

Banks set LTNCD, stock offerings

TWO OF THE COUNTRY’S banks are seeking to expand their capital through separate fund-raising exercises, they told the local bourse yesterday.

In separate disclosures on Tuesday, Rizal Commercial Banking Corp. (RCBC) said it is set to conduct a stock rights offering (SRO), while UnionBank of the Philippines (UnionBank) announced the launch of the initial tranche of its long-term negotiable certificates of time deposits (LTNCD).

The Yuchengco-led RCBC said its board of directors approved the stock rights offer that aims to raise up to P15 billion of fresh funds, seen to strengthen its capital base and fund its business expansion.

RCBC said proceeds from the offer will bolster its position in line with Basel 3 standards, although the lender noted that its current capital ratios are already above the central bank requirements.

The fresh funds to be raised from the SRO will also fund the continued growth of its businesses, particularly in loans, the bank said.

“RCBC seeks to focus on consumer, [small and medium enterprises], the middle market and the microfinance sector, and to pursue sustainable loan growth,” the lender said in the disclosure.

“RCBC also intends to use investments in technology to improve customer experience, broaden its customer base, and increase operational efficiency,” the lender added.

However, the timing of the SRO and other details on the offering have yet to be released, as these are still subject to the receipt of regulatory approvals and market conditions.

The SRO will be coming from the approval by the board of directors and the stockholders to raise RCBC’s authorized capital stock to P28 billion from P16 billion, or 2.6 billion authorized common shares from 1.4 billion.

Earlier, Metropolitan Bank & Trust Co. and Bank of the Philippine Islands also announced their planned SROs to fund their core business expansion and operations.

UNIONBANK
Meanwhile, Aboitiz-led UnionBank said yesterday that it has launched the first tranche of its planned LTNCD offerings.

The lender is offering at least P3 billion in LTNCDs to investors which it said will help improve its deposit maturity profile and support business expansion plans.

UnionBank’s offering has an oversubscription option. The instruments will have a tenor of five years and six months with an annual indicative rate of 4.125-4.375%.

This is the first of the bank’s approved P20-billion LTNCD program, which it previous said will carry tenors of five-and-a-half to 10 years. UnionBank plans to raise the entire amount over a period of one year.

The final rate of the LTNCDs will be determined shortly before the end of the public offer period which will run until Feb. 9. The issue date will be on Feb. 18.

Standard Chartered Bank will serve as the sole lead arranger and bookrunner, and will also serve as a selling agent together with UnionBank and Multinational Investment Bancorporation. The LTNCDs will be listed on the Philippine Dealing Exchange Corp., the lender said. — Karl Angelo N. Vidal

Nation at a Glance — (01/31/18)

News stories from across the nation. Visit www.bworldonline.com (section: The Nation) to read more national and regional news from the Philippines.

How PSEi member stocks performed — January 30, 2018

Here’s a quick glance at how PSEi stocks fared on Tuesday, January 30, 2018.

Inflation accelerates in 2017 for low-income households — PSA

Senate bill hopes to cut VAT rate to 10%, eventually to 8%

SENATOR Ana Theresia Hontiveros-Baraquel filed a bill on Tuesday seeking to reduce the Value Added Tax (VAT) rate from 12% to 10% in response to the effects of Republic Act (RA) 10963, or the Tax Reform for Acceleration and Inclusion (TRAIN) law.

Ms. Hontiveros filed Senate Bill 1671, which will be known as the Bawas VAT Act of 2018 if passed, amending sections 106 to 109 and 112 of RA 8424 or the Tax Reform Act of 1997.

The sections of the Tax Reform Act tackle VAT imposed on the sale of goods or properties, importation of goods, the sale of services and use or lease of properties as well as VAT-exempt transactions and tax credits.

If the bill is passed, the measure hopes to implement the reduced VAT rate by Jan. 1, 2019.

By Jan. 1, 2022, the bill also seeks a further reduction in the VAT rate to 8% if the previous year’s revenue from VAT, as reported in the budget of expenditures and sources of financing submitted to Congress, is equal to or exceeds 4.5% of gross domestic product (GDP).

In her explanatory note, Ms. Hontiveros said the proposed measure will “provide relief for the lower economic deciles of the population by lowering the VAT rate to 10%.”

“As our tax system becomes more efficient and corruption is weeded out by our modernizing revenue bureaucracy, we will want to rely less on taxes that are easily passed on to final consumers, such as the Value-Added Tax (VAT),” she said.

Ms. Hontiveros also noted that the bill also sought to align the country’s tax system with that of the Association of Southeast Asian Nation (ASEAN).

The proposed measure contains a trigger for VAT collections at the 10% rate; if the total hits 4.5% of GDP, that will pave the way for a further reduction “to achieve full alignment with the ASEAN norm of 8%.” — Camille A. Aguinaldo

The basics on Bitcoin for y’all who are clueless

Bitcoin. Bitcoin. Bitcoin. Everyone’s talking about it and frankly, it can get intimidating. Bitcoin is continuously gaining traction in the Philippines, prompting the government to raise concerns towards the virtual currency (VC) and all activities related to it. And as business‑minded millennials, we have to make sure we’re not left out. #FOMO

So here’s the basic info:

Used solely through digital platforms, meaning, unlike bills and coins, it cannot be held in one’s hand. It is used in purchasing products online, and is a form of investment for some because of its fluctuating value. As of writing, Bitcoin’s value per unit has plunged below the $10,000 from almost $20,000 just before 2017 ended.

The underlying technology behind Bitcoin and other electronic currencies is called “blockchain,” a network of interconnected ledgers or data bases that allows the easy access to and transfer of VC’s. (Here’s a related story about that)

Unlike physical currencies, VC’s are not regulated by any state or central bank, with the their security and verification as well as production highly dependent on cryptography. Hence, the attempt to regulate companies that serve as trading entities in many countries, including the Philippines.

The Bangko Sentral ng Pilipinas (BSP) in February last year issued an order requiring all VC providers present in the country to be under its watch. At present, BSP is in the process of authorizing 12 bitcoin exchange entities, following the approval of two VC exchanges last year.

The Securities and Exchange Commission (SEC) also recently issued an advisory, warning the public against investing in initial coin offerings (ICO), the counterpart of initial public offering in the startup scene. The announcement came after SEC’s previous announcement that it would look into the ICO of KROPS, a digital marketplace for farm produce led by Joseph Calata, chairman of now delisted agribusiness firm Calata Corp. The ICO was, later on, declared illegal.

Through an ICO, startups raise a certain amount of money for a project by selling a VC in return of another digital currency or fiat money. Fintech startup Qwikwire, for example, last December launched its ICO with an aim to raise $9 million for a new digital real‑estate market.

According to Zach Piester, co‑founder of venture development and innovation firm Intrepid Ventures, the country has a “really large and robust blockchain and [cryptocurrency] community.”

“Our hope in the ecosystem is that we can create new global financial systems based on the notion of transferring value without [a] third party,” Piester said during the first Blockchain & Bitcoin Conference Philippines last January 25 at EDSA Shangri‑La Hotel in Mandaluyong City. The event drew hundreds of local and foreign Bitcoin enthusiasts.

Jeremy Goodwin, CEO of peer‑to‑peer manufacturing network SyncFab, claims: “The reason why cryptocurrencies exist is that they were [a] product of financial crisis in 2008. With the corruption in the financial market and all the untrusted central banking system, they (cryptocurrencies) are [a] trust‑worthy medium of financial banking.” He added: “They can be used and de‑centralized and for which the system is set up by movement undertaken by some libertarians and some technologists who create alternatives to the existing financial, central banking system [in the form of] de‑centralized ledgers.”

Goodwin also said that cryptocurrencies are “meant to address double spending,” easing payment transactions by eliminating third party platforms.

For Luis Buenaventura, chief technology officer at BloomSolutions and author of the book “Reinventing Remittances with Bitcoin,” the number of people involved in VC trades is growing because of the “excitement behind the technology and the real‑world application of what blockchain is gonna do to transform many industries.”

“Humanity has proven itself not up to the task of managing its money. I think that our governments are particularly good at that, and we’ve seen it time and time again,” Buenaventura said.

“An alternative now exists that we trust more in math, in electricity, and in many ways [cryptocurrencies] feel particularly more sound as a solution.”

Central bank readies new risk buffer

By Melissa Luz T. Lopez
Senior Reporter

THE CENTRAL BANK is looking to introduce a new risk management measure that would require banks to set aside additional capital as reserves, this time to cover potential losses amid rapid loan growth.

Bangko Sentral ng Pilipinas (BSP) Governor Nestor A. Espenilla, Jr. said that the central bank is now looking to introduce the countercyclical capital buffer (CCyB) that will require big banks to maintain such a “sufficient capital base” at times of “excessive” credit growth.

This prudential tool is included in the international Basel 3 framework, although the central bank initially decided not to adopt the standard.

“This is part of the Basel III framework which the BSP had not included in our 2014 application of the revised capital standards. As we consider the remaining components of the Basel III agenda, our framework for the CCyB will be issued for comments in the first half of the year, including the calibration of the extent of the buffer,” Mr. Espenilla said in a recent e-mail to BusinessWorld.

The central bank chief said the measure is being studied in the face of the “potential buildup of systemic vulnerabilities” in the financial system.

The BSP joined other central banks in adopting the new set of Basel standards starting with the capital adequacy ratio (CAR) — the amount which banks need to deploy as buffers to protect themselves for possible episodes of funding crunch.

Currently, banks are required to keep funds on standby equivalent to 10% of their assets that pose significant potential risk to their health.

This is higher than the eight percent global standard.

Once imposed, the CCyB means big banks in the Philippines need to accumulate additional capital during a credit boom, on top of the regular CAR.

“In downturns, the regime should help to reduce the risk that the supply of credit will be constrained by regulatory capital requirements that could undermine the performance of the real economy and result in additional credit losses in the banking system,” according to CCyB guidelines published by the Bank for International Settlements (BIS).

Economists have been flagging the Philippine economy’s increased risk of overheating amid sustained double-digit growth in bank lending.

Mr. Espenilla has said that the economy is simply “warm but not red hot,” with the rapid increase in bank lending simply matching the pace of robust gross domestic product (GDP) growth.

Philippine GDP expanded by 6.7% in 2017, cementing the country’s place in the ranks of Asia’s fastest-growing economies — next to China’s 6.9% and Vietnam’s 6.8% — albeit slowing from the 6.9% pace recorded the preceding year.

At the same time, bank lending increased by 19.2% year-on-year as of end-November, according to latest available central bank data.

The BIS — which drafted the Basel III reform agenda — requires regulators to set a sufficient buffers relative to banks’ risk-weighted assets.

The BIS said authorities are expected to look at a country’s credit-to-GDP ratio as a benchmark in prescribing buffer levels. The Philippines posted a credit-to-GDP ratio of 63.6% as of end-June 2017 which is among the lowest in Asia.

A central bank may choose to raise capital requirements to temper credit growth.

Sought for comment yesterday, Union Bank of the Philippines President and Chief Operating Officer Edwin R. Bautista said introducing the CCyB “indeed enhances risk management” as it allows lenders to cover losses when the credit cycles goes on a downturn.

“As to whether banks would be able to meet the requirement, it would depend on the specifics that BSP will use in crafting the circular,” Mr. Bautista said in a mobile text message.

“Nonetheless, please take note that Philippine banks have been well-capitalized comfortably above minimum standards.”

Other Basel III measures currently in place in the Philippines include the 30-day liquidity coverage ratio and the framework for domestic systemically important banks. A five percent minimum leverage ratio will also kick in by July which seeks to avert excessive debt exposures among banks.

Gov’t, PCCI to feel pulse on tax reform

THE GOVERNMENT has teamed up with the Philippine Chamber of Commerce and Industry (PCCI) for a nationwide road show this quarter designed to drum up support for Republic Act No. 10963 — the first of up to five planned tax reform tranches — and to feel businessmen’s pulse on the proposed second package that cuts the corporate income tax (CIT) rate and streamlines fiscal incentives, the Department of Finance (DoF) said in a statement yesterday.

DoF said it is undertaking the effort in partnership with the Participatory Governance Cluster-Open Government Partnership led by the departments of Budget and Management and of Interior and Local Government as well as with PCCI, and with the support of the United States Agency for International Development’s Facilitating Public Investments Project.

RA 10963, or the Tax Reform for Acceleration and Inclusion Act that was enacted on Dec. 19 last year, cuts personal income tax rates and offsets the expected foregone revenues by hiking or introducing consumption taxes on fuel, automobiles, sugar-sweetened drinks, tobacco products, coal, minerals, cosmetic surgery and some investment products, among other items. The enacted version of this first package is estimated to yield some P90 billion in additional revenues in the first year of enforcement, down from P133.8-157.2 billion originally after provisions were toned down.

The DoF submitted to the House of Representatives on Jan. 15 the second package, which will cut the CIT rate gradually to 25% from 30% over the next five years in order to put the Philippines at par in this regard with its closest Southeast Asian competitors like Indonesia, Thailand and Vietnam and will make up for the foregone revenues by scrapping redundant fiscal incentives that have been costing the government some P300 billion a year. The DoF hopes to secure this package’s enactment in time for start of enforcement in January 2019.

The department said the planned “caravan” will preach the merits of tax reform in Bacolod City (Jan. 31), General Santos City (Feb. 7), Subic/Clark (Feb. 13), Zamboanga City (Feb. 21), Makati City (Feb. 28), Cebu City (Mar. 2), Baguio City (Mar. 7) and Tacloban City (Mar. 23).

DoF Undersecretary Karl Kendrick T. Chua and Assistant Secretary Ma. Teresa S. Habitan will lead speakers from the government, while lawyers Tomasa “Tammy” H. Lipana and Benedicta “Dick” Du-Baladad, co-chairpersons of PCCI’s taxation committee, will represent the business sector. Lawmakers from both chambers of Congress have also been invited to speak in the road show.

The DoF statement quoted PCCI President Ma. Alegria S. Limjoco as saying that the road show will “solicit… business sentiments and positions on the proposed tax measure.”

“We fully recognize the efforts of government to raise revenue to support its infrastructure projects and we hope that the proposed measure, once passed into law, would be beneficial for everyone,” she said.

It also quoted Ms. Du-Baladad as saying “[i]t is high time the granting of tax incentives is rationalized to remove the redundancies and make incentives clearer and more accountable.”

DoF’s proposed bill will repeal 150 laws granting fiscal perks and replace them with an omnibus law covering the 14 investment promotion agencies.

At the same time, PCCI Taxation director Edgardo Lacson said: “We cannot discount the fact that our country has the highest corporate income tax rate in ASEAN (Association of Southeast Asian Nations).”

“There is a need to reduce the rates to a level that will make us competitive in a field of countries competing for the same direct investment funds.”

But Tax Management Association of the Philippines President Raymund S. Gallardo said last Sunday that DoF’s plan to make the graduated CIT rate cut contingent on the raising of at least P26 billion per year from a streamlined fiscal perks regime could turn off investors. — Elijah Joseph C. Tubayan

Improved anti-dengue vaccine seen from mess

CHICAGO — New dengue vaccines being developed by Takeda Pharmaceuticals Co. Ltd. and US government scientists are poised to provide a safer alternative to Sanofi’s Dengvaxia, according to vaccine experts, because they already take into account some of the issues that sidelined the product last year.

Sanofi revealed in November that Dengvaxia — the world’s first dengue vaccine — might increase the risk of severe disease in people who had never been exposed to the virus.

The news prompted an uproar in the Philippines, where more than 800,000 school-age children had been vaccinated.

Next-generation vaccines by Japan’s Takeda and the US National Institutes of Health (NIH), in conjunction with Brazil’s Butantan Institute, are now in late-stage testing.

They both differ significantly from Dengvaxia, which may increase the chances for a stronger, more durable immune response, according to more than a dozen dengue experts interviewed by Reuters.

They expressed especially high hopes for the NIH vaccine, which protected 100 percent of volunteers who received it in a small study.

Merck & Co., Inc. holds an exclusive license for the NIH vaccine in the United States, Canada, China, Japan and the European Union, and plans to begin its own trials in the first half of 2018.

It’s too early to say whether either candidate will ultimately succeed, and experts await data from large, late-stage clinical trials.

And while Sanofi’s early safety troubles may delay licensing of new vaccines for a few years as global regulators seek assurances from longer-term data, the increased scrutiny should result in a better, safer product, they said.

“We’ve learned a tremendous amount about dengue from the Sanofi vaccine,” said Dr. Anna Durbin, a researcher at the Johns Hopkins Bloomberg School of Public Health who helped develop the NIH vaccine. “There is hope the two candidates coming down the pike can provide the benefit of a good dengue vaccine without the risk.”

LESSONS LEARNED
Dengue is the world’s fastest-growing infectious disease, afflicting up to 100 million people worldwide, causing half a million life-threatening infections and killing up to 25,000 people, mostly children, each year. An effective vaccine could be worth more than $1 billion globally, according to industry analysts.

There are four distinct types of dengue. A first infection with any one of them can increase the chances of severe disease when exposed to a second.

Experts say an effective vaccine must protect against all four types at once. A weak response to one of them could act like a first infection and leave a person vulnerable to severe disease when exposed a second time.

That is what appears to have happened with Sanofi’s Dengvaxia, according to vaccine experts.

“It wasn’t a uniformly high level of response to all four subtypes (of dengue) simultaneously,” Dr. Anthony Fauci, director of the NIH’s National Institutes of Allergy and Infectious Diseases, said in an interview.

Sanofi’s late-stage clinical trials, which were designed in 2009, collected blood samples from only 10-15% of study participants before they were vaccinated.

As a result, it was impossible to know when the studies were published in 2015 whether risks were greater in children who had never been exposed to dengue, said Dr. Su-Peing Ng, Sanofi’s global medical head, in an interview.

To answer this question, Sanofi developed a special test to re-analyze its results, leading to the November 2017 disclosure.

“We’ve been extremely transparent with our data,” Ms. Ng said, adding that the company consulted with the field’s leading experts as it was developing its vaccine.

Clinical trials testing the two new vaccines both require blood samples for all participants before they are vaccinated so they can quickly identify any similar risks.

Dr. Stephen Whitehead, who developed the NIH vaccine, said in a 2016 review that the long-term follow up from Sanofi’s studies “was instrumental in identifying safety concerns that are currently being investigated.”

IMMUNE RESPONSE
Dengvaxia uses a widely effective yellow fever virus vaccine as its genetic backbone. To induce an immune response to dengue, certain yellow fever genes were swapped out for dengue genes.

“It seemed like a bright idea 20 years ago,” said dengue expert Dr. Scott Halstead, an adjunct professor at the Uniformed Services University of the Health Sciences in Bethesda, Maryland.

In hindsight, Mr. Halstead said, simply splicing select dengue genes into a yellow fever vaccine may not present enough of the virus to the immune system to induce full protection.

Instead of yellow fever, Takeda’s vaccine, TAK-003, is based on a weakened version of a live dengue 2 virus.

“We’ve taken a dengue 2 virus backbone and inserted elements of dengue 1, 3 and 4,” said Dr. Rajeev Venkayya, president of Takeda’s global vaccine business unit.

That’s important, Venkayya said, “because it exposes an individual that is immunized to a broad range of proteins on the outside and the inside of the virus, which allows individuals to generate a broad immune response.”

Data published in November in Lancet Infectious Diseases showed Takeda’s vaccine produced responses against all four virus types, regardless of previous dengue exposure. There were no safety concerns.

Takeda’s vaccine is being tested in 20,000 children aged four to 16 in Asia and Latin America. Initial data are expected in late 2018.

Venkayya said the company’s research has shown the vaccine, given in two doses, can produce both antibodies to dengue as well as a second type of response in which immune cells — known as CD8-positive T cells — recognize and kill virus-infected cells.

Several researchers suspect exposure to the full spectrum of dengue proteins is key to developing a fully protective vaccine.

Johns Hopkins’ Durbin said the presence of T-cells triggered by non-structural proteins in dengue 2 could help clear the virus before people become sick.

But, like Sanofi’s Dengvaxia, the Takeda vaccine appears to produce an unbalanced antibody response, with the highest protection offered against dengue 2.

In a July 2017 paper published in Cold Spring Harbor Perspectives in Biology, Mr. Halstead said that it is also not clear whether Takeda’s vaccine will provoke T-cell immunity to the other three dengue viruses, clouding its potential to succeed.

The NIH vaccine, called TV003/TV005, also features weakened versions of live dengue, but three of the four components — dengue 1, 3 and 4 — are based on whole dengue viruses. The fourth component is based on a dengue 4 backbone with dengue 2 genes spliced in.

It has been shown to provoke a strong antibody response to all four types of dengue in a single shot, as well as producing T-cell immunity.

“It appears to be a true, protective, one-dose vaccine,” Mr. Halstead said.

Brazil’s non-profit Butantan Institute is testing the vaccine in some 17,000 participants in 14 areas with widespread dengue.

“Though you never, ever, definitively predict until after everything is completely over, everything we’ve seen on the preliminary work on that looks pretty good,” Mr. Fauci said. — Reuters